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KMID : 1094020160330050270
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Journal of Veterinary Clinics
2016 Volume.33 No. 5 p.270 ~ p.273
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Evaluation of the Agreement between Immunodot Assays and Intradermal Skin Testing or Favrot Diagnostic Criteria in Canine Atopic Dermatitis
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Cho Sun-Hyung
Kang Ji-Houn
Yang Mhan-Pyo
Kang Byeong-Teck
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Abstract
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This study was undertaken to identify differences between atopic and non-atopic dogs in three rapid screeningimmunodot assays as well as the ability of the assays to predict the results of intradermal skin testing (IDST) or Favrotdiagnostic criteria (FDC). Twenty-nine dogs diagnosed with canine atopic dermatitis (CAD) were selected as the atopicgroup. Twenty-five dogs without CAD were included as the non-atopic group. Three types of immunodot assays wereconducted on all serum samples from both groups: Allercept E-screen 2nd generation (ES2G), Canine Allergic TendencyReference Test (ALERT), and Asan Easy Test Canine IgE (AETC). IDST, which included 39 allergens, and immunodotassays were performed concurrently in 13 dogs from the atopic group and compared. While there were no significantdifferences in positivity between the two groups in the evaluation of ALERT (P = 0.435) and AETC (P = 0.313),positivity in ES2G testing was significantly higher in the non-atopic group than the atopic group (P = 0.038). TheES2G, ALERT, and AETC results showed fair (κ = 0.235), slight (κ = 0.133), and slight (κ = 0.014) accordance withIDST, respectively. The outcomes of ES2G, ALERT, and AETC indicated poor (κ = ?0.211), slight (κ = 0.106), andslight (κ = 0.087) agreement with FDC. In conclusion, rapid screening immunodot assays were not useful for thediagnosis of CAD. These assays may provide a supplementary method for predicting the results of IDST in atopic dogs.
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KEYWORD
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canine atopic dermatitis, immunodot assay, intradermal skin test, Favrot diagnostic criteria
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